This time, the theme is about liposomes, which we were most particular about in product development.
 
Lypo-C [Lypo-capsule] We hope that you will understand the “liposomes” that are the most important feature of vitamin C, be aware of the purpose of your own intake, and experience a further “experience”. I know.
 
This time, we will dig deep into these liposomes and introduce Lypo-C liposomes = “Lypo-capsule”.
 
The article is a little scientific, but I hope that you can understand that you chose this product without a doubt.
 

History of liposomes

First, let me briefly introduce the history of liposomes.
 
Liposomes were discovered by Dr. ADBangham in England in 1964, and his research has spanned 50 years.
 
Liposomes, which are artificial cell membranes made of the same lipid bilayer as cell membranes, were originally used as drug carriers (DDS [drug delivery systems]) to efficiently deliver drugs such as anticancer drugs in the medical field. has been used. Encapsulating drugs in liposomes not only delivers the drug to cells, but also enhances the main pharmacological effect and reduces side effects.
However, it has been a difficult technology to manufacture stably standardized liposomes.

It can be said that the history of liposome research has been a challenge to "size control" and "stability" in order to maximize its function as a "carrier".
 
The liposomes in the first “Liposome Vitamin C Supplement” were made overseas.
Their sizes ranged from 800 nm to 1,000 nm, and they were large and non-uniform.
After that, liposomal vitamin C with a size of 300nm to 500nm was developed, and it became available in the form of import in Japan.
 
And now, after many years, we are finally able to produce it domestically.
 
Japan's first "liposome vitamin C supplement", this is Lypo-C [Lypo-capsule] vitamin C.
The size of liposomes was almost uniform at 100 nm.
 
The size of 100 nm is about 1/100 of the diameter of human capillaries and cells.
I think you'll find that it's very subtle.
 

Why we stick to 100nm size

When developing Lypo-C, we were particular about the size of this liposome as a supplement for use in medical settings.
This is because controlling the size of liposomes to be smaller and uniform is the secret to smoothly delivering encapsulated vitamin C to cells.
 
Naked vitamin C, not encapsulated in liposomes, is absorbed into the body through specific openings in the digestive tract.
However, liposomal vitamin C is absorbed directly from the intestinal wall without passing through specific pores, and can pass smoothly into the blood.
Liposomes stay in the blood moderately, and when they reach the cells, they assimilate with the cell membranes and efficiently deliver vitamin C into the cells.
The size that maximizes these features of liposomal vitamin C was around 100 nm.
 

Commitment to uniformity

Liposomes are not just small in size. Uniformity is required.
When measuring the particle size distribution of Lypo-C (indicator indicating what size particles are contained in what proportion), the graph has one peak and a size of about 100 nm (90 to 140 nm). You can see that it is equalized to .
Uniform size is a very important point for liposomes and a feature of Lypo-C.
 
One of the reasons why uniformity is important is that liposomes that are large and non-uniform tend to agglomerate.
That is, large and irregularly sized liposomes may aggregate, resulting in larger liposomes and reduced bioavailability.
 
At 100 nm, the nearly uniform size means that it is less prone to agglomeration.
 
Lypo-C is manufactured in a clean room at the level of manufacturing pharmaceuticals, and the particle size distribution is checked each time to deliver liposomal vitamin C in a stable state.
 

Commitment to product development

We believe that if we cannot find the ideal product in the market, we need to create it ourselves.
 
We have developed Lypo-C in pursuit of such an "ideal".
 
The products we make are "products that professionals can use and satisfy our customers", and "we use the highest quality and most reliable products that can be selected in the world at that time". Based on this stance, we have developed a domestically manufactured 100nm liposome capsule, “Lypo-capsule”.
 
We hope that everyone who picks up Lypo-C will be able to experience a sufficient amount of vitamin C.